磁共振对肥大性下橄榄核变性的诊断

MRI diagnosis of hypertrophic olivary degeneration

目的:分析肥大性下橄榄核变性(HOD)的MRI表现,以提高对该病的认识。方法:对8例HOD的MRI表现及引起该病的病因进行回顾性分析。自原发病变出现到MRI检查时间为3～30个月。结果:MRI图像均表现为下橄榄核(ION)部位T2WI高信号,T1WI呈等或稍低信号,有3例双侧ION部位出现高信号,5例ION体积有不同程度增大。8例病人中原发病变为中脑梗塞3例,桥脑出血2例,小脑出血2例、梗死1例。结论:MRI能清晰显示Guillain-Mollaret三角区病变所致ION变化,提高对该病的认识可以避免误诊。

Objective： To analyze MRI characteristics of hypertrophic olivary degeneration（HOD） in order to improve our knowledge for this disease. Materials and Methods： MRI findings in all 8 patients with HOD and the inciting lesions were reviewed. The intervals from ictus to MR scan were 3-30 months. Results： The region of inferior olivary nucleus（ION） presented high intensity on T2WI and iso- or mild hypo-intensity on T1WI in all 8 patients. Bilateral ION showed high-signals in 3 cases. Enlargement of the ION in 5 patients also was noted. The primary lesions were also located-three with midbrain infarctions, two with pontine tegmental hemorrhages and two with hemorrhages, one with infarction in the cerebellum. Conclusion： MR images may clearly demonstrate the changes of ION in patients with a lesion in the triangle of Guillain and Mollaret. Misdiagnosis may be avoided by improving the recognizition for this disease.