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恶性淋巴瘤血清sApo-1/Fas检测及临床意义 被引量:2

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摘要 目的探讨恶性淋巴瘤血清sA po-1/F as水平变化及临床意义。方法应用酶联免疫吸附试验法(EL ISA)检测43例恶性淋巴瘤患者化疗前后血清sA po-1/F as水平,同时检测21例正常人作对比分析。结果恶性淋巴瘤血清sA po-1/F as水平明显高于正常对照组(P<0.01),与临床分期和化疗效果有关,与年龄、性别、病理类型、既往治疗、原发部位、局部巨大肿块无关,Ⅱ、Ⅲ、Ⅳ期明显高于Ⅰ期,化疗有效者血清sA po-1/F as明显低于化疗前(P<0.05),接近正常对照组(P>0.05),化疗无效者血清sA po-1/F as略高于化疗前(P>0.05),明显高于正常对照组(P<0.01)。结论血清sA po-1/F as有望成为恶性淋巴瘤发生、发展,治疗效果和预后观察的有价值指标。
出处 《实用肿瘤杂志》 CAS 2006年第2期138-140,共3页 Journal of Practical Oncology
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  • 1Kotani T,Aratake Y,Kondo S,et a1.Expression of functional Fas antigen in adult T—cell leukemia[J].Leukemia Res.1994.18:305—310.
  • 2Munker R, Lubbert M,Yonehara S,et al. Expression of the Fas antigen on primary human leukemia cells[J]. Ann Hematol, 1995,70:15-- 17.
  • 3Cheng J,Zhou T, Liu C, et al, Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule [J], Science,1994,263 : 1759-- 1762.
  • 4Oehm A,Behrmann l,Falk W,et al. Purification and molecularcloning of the APO-1 cell surface antigen,a member of the tumor necrosis factor/nerve growth fact or superfamily. Sequence identity with the Fas antigen[J]. J Biol Chem, 1992,267 : 10709-- 10715.
  • 5Papoff G, Cascino I, Eramo A, et al. An N-terminal domain shared by Fas/Apo(CD95) soluble variants prevents cell deathin vitro[J]. J Immunol,1996,156(12):4622--4630.
  • 6Knipping E, Debatim K M, Stricker K,et al. Identification of soluble APO-1 in supernatants of human B-and T-cell leukemias[J ]. Blood, 1995,85 : 1562 -- 1569.
  • 7Sugahara K, Yamada Y, Hiragata Y, et al, Soluble and membrane isoforms of Fas/CD95 in fresh adult T-cell leukemia(ATL) cells and ATL-cell lines[J]. Int J Cancer, 1997,72 :128--132.
  • 8Landowski T H, Shain K H, Oshiro M M, et al. Myeloma cell selected for resistance to CD95^- mediated apoptosis are not cross resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation[J]. Blood, 1999. 94, 265--274.
  • 9Gajate C, Mollinedo F. The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells[J].Blood,2001,98(13):3860-3863.
  • 10Fumarola C, Zerbini A, Guidotti GG. Glutamine deprivation-mediated cell shrinkage induces ligand-independent CD95 receptor signaling and apoptosis [J].Cell Death Differ, 2001,8(10):1004-1013.

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