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奥沙利铂联合5-氟尿嘧啶、亚叶酸钙治疗晚期消化道肿瘤的临床观察 被引量:10

Clinical Observation of Oxaliplatin plus 5-fluorouracil Leucovorin in Treatment of Advanced Gastrointestinal Carcinoma
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摘要 目的 观察奥沙利铂联合5-氟尿嘧啶、亚叶酸钙治疗晚期消化道肿瘤的临床疗效及不良反应。方法 64例均有组织病理学诊断及可评价客观指标。采用奥沙利铂130mg/m^2dl,亚叶酸钙(CF)200mg/m^2+5-氟脲嘧啶300mg/m^2d1~5化疗,3周为一周期,三周期评价疗效。结果 64例均可评价疗效和不良反应。CR4例、PR33例、SD19例、PD8例。其中胃癌有效率为55.9%,结肠癌68.7%。直肠癌50.0%。主要的不良反应为骨髓抑制,消化道粘膜反应,感觉神经毒性但发生率较低。结论 奥沙利铂联合5-氟脲嘧啶、亚叶酸钙治疗晚期消化道肿瘤有效率较高,不良反应可以耐受。 Objective To evaluate the curative effect and toxicity of Oxaliplatin plus 5-fluorouracil, Leucovorin in treatment of Advanced Gastrointestinal Carcinoma. Methods 64 pathologically proved cases of gastrointestinal carcinoma were treated with intravenous infusion of Oxaliplatin 130mg/m2 on the first day, and 5-fluorouracil 300mg/m^2 + Leucovorin 200mg d1-5 repeated every 3 weeks, and the clinical response was assessed after three cycle. Results It shows that objective response rate was observed CR4, PR33, NCI9, PDS. An overall effective rate of gastric carcinoma 55.9% colon carcinoma 68.7% rectal carcinoma 50. 0%. The main side effects inclued bone marrow suppression, mucositis, sensory neuritis, et al. Conclusion Oxaliplatin plus 5-fluorouracil, Leucovorin is effective for advanced gastrointestinal carcinoma and toxicities are well tolerated.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2006年第4期268-269,共2页 Cancer Research on Prevention and Treatment
关键词 消化道肿瘤 奥沙利铂 5-氟脲嘧啶 亚叶酸钙 联合化疗 Advanced gastrointestinal carcinoma Oxaliplatin 5-fluoruracil, Leucovorin Combination chemotherapy
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