不同温度煅烧骨作骨形态发生蛋白载体的试验研究

An Experimental Research on Different Temperature Sintered Bone as Carrier of Bone Morphogenetic Protein

采用不同温度天然煅烧骨与骨形态发生蛋白复合物进行兔桡骨骨缺损修复的动物试验。发现600℃的煅烧骨与骨形态发生蛋白的复合材料(BM P/SB)与900℃及1 200℃的BM P/SB材料在诱导成骨及修复骨缺损中作用不如后两者。900℃及1 200℃的BM P/SB材料在新骨形成量上要高于600℃的BM P/SB材料(P<0.05),而后两者间无明显差别(P>0.05)。但900℃的煅烧骨材料力学强度大,制备温度相对低,故经济效益明显。研究提示900℃的的煅烧骨与600℃、1 200℃的煅烧骨相比,更适于用作骨形态发生蛋白的载体。

This study was conducted to find perfect temperature sintered bone as carrier of bone morphogenetic protein（BMP）. The different temperature active sintered bones, which were made up of calcine bone and bone morphogenetic protein, were implanted into the defects of rabbit radius. Compared with the sintered bone of 600℃, the sintered bone of 900℃ and 1 200℃ could induce more pieces of bone formation and be replaced by new bone. There were more pieces of new bone formation in sintered bone of 900℃ and 1 200℃ than those in sintered bone of 600℃ （P〈0. 05）. There was no difference between the sintered bone of 900℃ and 1 200℃ （P〉0. 05）. In comparison with the sintered bone of 600℃ and 1 200℃, the sintered bone of 900℃ may be the choicest carrier of bone morphogenetic protein.