磷酸钙生物材料固有骨诱导性的研究现状与展望

Research Development and Prospect of Calcium Phosphate Biomaterials with Intrinsic Osteoinductivity

磷酸钙陶瓷因与骨的无机组成相似,具有良好生物相容性和骨引导性,无抗原性,被广泛应用于骨缺损修复,但一直认为磷酸钙陶瓷是一类仅具有骨引导性,而无骨诱导性的生物活性材料。大量研究表明通过材料自身组成和结构优化,可赋予磷酸钙陶瓷骨诱导性。本文对磷酸钙骨诱导现象发现和确证、骨诱导过程和机制、影响骨诱导性的材料学因素和骨诱导与动物种属关系、骨诱导相关的间充质细胞来源、以及骨诱导性材料的应用研究现状进行综述,并对磷酸钙生物材料骨诱导性及相关的研究方向予以展望。

Calcium phosphates ceramics are frequently used as bone substitute materials in clinics because they are similar to the bone in mineral phase, they are of no antigenicity, and they have good biocompatibility as well as excellent osteoconductivity, The question as to whether calcium phosphate biomaterials possess osteoinductivity has been debated for a long time. Up to now, extensive fundamental studies and clinical application have demonstrated that calcium phosphate ceramics with special structure may induce bone formation in soft tissue, In this paper are reviewed the discovery and confirmation of calcium phosphates ceramics with intrinsic osteoinductivity, the process and mechanism of osteoinduction, and the relationship between osteoinductivity of calcium phosphate materials and animal species, the mesenchymal stem cells related to osteoinduction, the application of osteoinductive biomaterials. The researches directed toward to the osteoinduction of calcium phosphate are prospected.