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核酸适体技术研究进展 被引量：20

Current Reviews in Aptamers
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摘要 核酸适体(aptam er)指的是经体外筛选技术SELEX(指数富集配体系统进化)筛选出的能特异结合蛋白质或其他小分子物质的寡聚核苷酸片段,对可结合的配体有严格的识别能力和高度的亲和力。核酸适体在生物传感器、新药开发以及纳米技术等方面有着广泛的用途,本文对核酸适体近两年的研究进展进行综述。 Aptamers are oligo-nucleotides which exponential enrichment） in vitro, it can bind protein Researches on aptamers have achieved much progress article has reviewed the researches and applications of are selected by SELEX （systematic evolution of ligands by or other small molecules with high specificity and affinity. in biosensor, drug development and nano technology. This aptamers in the past two years.
作者 王成刚 莫志宏
机构地区 重庆大学生物工程学院 重庆大学化学化工学院
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2006年第2期463-466,共4页 Journal of Biomedical Engineering
关键词 核酸适体 指数富集配体系统进化 生物传感器 新药开发 纳米技术 Aptamer Systematic evolution of ligands by exponential enrichment（SELEX） Biosensor Drug development Nano technology
分类号 Q78 [生物学—分子生物学]
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参考文献23

  • 1Ellington AD,Szostak JW.In vitro selection of RNA molecules that bind specific liganes.Nature,1990; 346(30):818.
  • 2Jiang YX,Zhu CF,Ling LS.Specific aptamer-protein interaction studied by atomic force microscopy.Anal Chem,2003; 75:2112.
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  • 5刘晓,李长友,陈元鼎.指数富集配基的系统进化原理及应用进展[J].生物化学与生物物理进展,2002,29(6):855-859. 被引量：3
  • 6Kevin NM,Kirk BJ,Carol MJ.High affinity ligands from in vitro selection:Complex targets.Biochemistry,1998; 9(6):2902.
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  • 10Ho HA,Leclerc M.Optical sensors based on hybrid aptamer conjugated polymer complexes.J Am Chem Soc,2004; 126(5):1384.

二级参考文献28

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生物医学工程学杂志
2006年 第2期

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