氯氮平、利培酮和奎硫平对精神分裂症体重、血糖的影响

Influences of the clozapine,risperidone and quetiapine on the body weight and blood sugar level in the treatment of patients with schizophrenia.

目的分析抗精神病药对首发精神分裂症患者体重及血糖的影响。方法将48例首发精神分裂症患者分为3组,并分别单用氯氮平、利培酮、奎硫平治疗8周。于治疗前及治疗后第2、4、6及8周末分别测查体重、血糖。结果3个组的患者治疗后体重均有所增加,氯氮平组第4周末血糖明显升高,体重与血糖升高呈明显正相关。结论氯氮平、利培酮及奎硫平均能引起体重增加,而氯氮平引起血糖升高可能与此相关,应予以重视。

Objective To analyse the influences of clozapine, risperidone and quetiapine on the body weight and blood glucose level in the treatment of patients with schizophrenia. Method 48 schizophrenic patients were divided into 3 groups,with treatment of clozapine, risperidone and quetiapine respectively for 8 weeks. Body weight and blood glucose level were measured 2nd, 4th, 6th and 8th week after the treatment. Results There was increased in body weight in each group. Blood glucose level was significantly elevated in patients with clozapine group after 4 weeks treatment, and was posi- tively correlated with body weight. Conclusion Clozapine, risperidone and quetiapine all cause elevation in body weight, which the elevation in blood glucose by clozapine may be correlated with. More attention should be paid to this.