肝能滴丸在鸭体内对鸭乙型肝炎病毒感染的治疗效果

Curative Effect of Ganneng Dropping Pills on Ducks in vivo Transfected by DHBV

目的:观察肝能滴丸对鸭乙型肝炎病毒感染的治疗效果。方法:采用一日龄北京鸭静脉注射鸭乙型肝炎病毒,7d后开始给鸭口服肝能滴丸125、250和500mg/kg 3个剂量,每天2次,给药10d,观察药物对鸭的毒性和鸭血清乙肝病毒DNA(DHBV-DNA)的影响。结果:肝能滴丸在250mg/kg组对鸭乙型肝炎病毒感染有可重复的显著治疗效果。500mg/kg组有较好的效果,125mg/kg组无抑制作用。结论:肝能滴丸有良好的抗鸭乙肝病毒效果。

Objective：To observe the curative effect of Ganneng Dropping Pills on ducks transfected by DHBV. Methods：The Beijing ducks of one day age injected DHBV（iv） were feeding Ganneng Dropping Pills of different dose concentrations（ 125,250 and 500mg/kg） two times a day, then observe the influence of this drugs on DHBV-DNA and on the toxicity to ducks seven days later. Results：The middle-dose concentration（250mg/kg） showed apparent curative effect on ducks,and the high-dose concentration（500mg/mL） showed definite effect, while the low-dose concentration（ 125mg/ mg） showed no inhibitory effect on DHBV. Conclusion： Ganneng Dropping Pills have curative effect on ducks in vivo transfected by DHBV.