基质金属蛋白酶-2在子宫内膜癌中的表达及意义

Expression of Matrix Metalloproteinase-2 in Endometrial Carcinoma

目的:检测基质金属蛋白酶-2(MMP-2)在子宫内膜癌中的表达,分析其与临床病理特征间的关系,以探讨其在子宫内膜癌发生发展中的作用。方法:用免疫组化SP法检测45例子宫内膜癌中MMP-2的表达,另选12例增生子宫内膜和20例正常子宫内膜作为对照。结果:MMP-2蛋白在正常子宫内膜、增生子宫内膜中的表达无显著性差异(P>0.05)。子宫内膜癌组MMP-2表达高于对照组(P<0.05)。MMP-2在子宫内膜癌中、低分化组的表达高于高分化组(P<0.01)。在有肌层浸润标本中的表达高于无肌层浸润者(P<0.05)。结论:子宫内膜癌中MMP-2表达增强,与子宫内膜癌的发生、发展有关。

Objective： To detect the expression of matrix metalloproteinase - 2（ MMP- 2）in endometrial carcinoma and study its relationship with clinicaopathological features so as to address the roles of MMP - 2 in the development of this malignant tumor. Methoils： A total of 45 endometrial carcinoma tissue blocks were obtained and stained using immunohistochemical streptavidin peroxidase technique with rnonoclonal antibody against MMP - 2, another 12 hyperplasia endometrium and 20 normal endometrium tissue blocks were used as control group.Results： There were no significant differences in the expression of MMP- 2 in normal endometrium and hyperplasia endometrium （ P 〉 0.05）. The expression rates of MMP - 2 were signilicandy higher than that of control group （ P 〈 0.05） .The expression of MMP- 2 in group of middle and low differentiated carcinoma was significandy higher than that in group of highly differentiated carcinoma（ P 〈 0.01 ）, and the expression of MMP - 2 also significandy higher in the group with myometrium invasion than that in the group without myometrium invasion （ P 〈 0.05）. Conclusion： MMP - 2 expression significantly increased in endometrial carcinoma, indicating that increased MMP- 2 may play a role in the development of endometrial carcinoma.