CF/5-Fu联合DDP方案两种给药方法治疗晚期胃肠道腺癌的临床观察

CALICIUM FOLINATE/5-FLOUOROURACIL COMBINED WITH CF/5-FU COMBINE WITH DDP TO TREAT ADVANCED GASTROINTESTINAL ADENOCINOMA

目的 观察CF／5-Fu联合DDP两种给药方法治疗晚期胃肠道腺癌的临床疗效及不良反应。方法 治疗组静点CF（200mg／m^2）2h，d1，静冲5-Fu（500mg／m^2）后使用化疗泵持续静脉滴注5-Fu（2．5g／m^2）48h，静点DDP（20mg／m^2·d）连用5天；对照组静点CF（100mg／m^2）2h，d1～5，静点（5-Fu500mg／m^2）4h，d1～5，余同治疗组。结果 治疗组总有效率（CR＋PR）为68．7％，对照组总有效率为26．9％，临床疗效统计学处理用确切概率法，组间差异有显著性（P〈0．05）。血液性毒性的发生率，恶心、呕吐的发生率两组无统计学差异（P〉0．05），腹痛腹泻发生率治疗组毒副反应较对照组低，两组统计学处理差异有显著性（P〈0．05）。结论 将5-Fu静点改为持续静脉灌注治疗晚期胃肠道腺癌，疗效好，毒副反应轻，值得临床推广应用。

Objective To observe the efficacy and toxicity of Folinic acid plus 5 - Fluorouracil combined with cisplatin in treatment of advanced gastrointestinal adenocinima. Methods Treatment group, thirty - two hospitalized patients with advanced gastrointestinal adenocinima were given in subsequence calcium folinate with a dose of 200 mg/m^2 on d1 in 2 hours, 5 - Fluorouracil with 500 mg/m^2 by injection venosa, 5 - Fluorouracil with 2.5g/ m^2 continuous infusion 48 hours. Control group, by studied retrospective twenty - six patients were given calcium folinate with 100mg/m^2 in 2 hours and 5 - Fluorouracil bolus with 500 mg/m^2 by in venas guttatin on d1- 5. Results The total response rate in treatment group （68.7%） is higher than that in control group （26.9%）. The side effects of blood toxicity, nausea and vomiting showed in treatment group, and it showed no statistics differences. The onset of bellyache and diarrhea were significantly lower in experimental group than those of control group （ P 〈 0. 05 ）. Conclusion Changing ment for patients with 5 - Fluorouracil infusion into 5 - Fluorouracil continuous infusions a good methods in treatadvanced gastrointestinal acenocinoma and is worth to be popularized.