新型水基磁流体的制备及其生物磁热效应研究

The preparation of novel aqueous ferrofluid and biomagnetic heat effect

以化学共沉淀法合成出Fe3O4纳米超顺磁性颗粒,并首次采用泛酸(D-pantothenic acid)对粒子进行表面化学修饰,制备出稳定分散在水中的水基磁流体。通过TEM对磁流体表征显示,随着纳米Fe3O4颗粒表面改性泛酸分子的增加,磁流体分散状况显著改善。FT-IR光谱表明泛酸分子与纳米Fe3O4表面羟基发生化学键合;并分别用XRD、TG对水基磁流体进行表征,同时对其在交变磁场中的热效应进行了研究,产热比功率高达146.64W/g,在肿瘤磁热疗方面具有较大应用前景。

This paper has described the preparation of magnetite superparamagnetic particles by co-precipitation method, the original modification on the surface of magnetite by novel modification reagent（ D-pantothenic acid） and obtaining the steady aqueous ferrofluid well-dispersed in the deionic water. The dispersion state of aqueous ferrofluid becomes better with increasing pantothenic acid molecules coupling with the magnetic particles by TEM observation. FT-IR spectrum shows D-pantothenic acid molecule was covalent bonds with the magnetite surface. We characterize the aqueous ferrofluid through TEM, XRD, and also measure the heat power by the SAR measurement, SAR achieves 146.64W/g Fe3O4. Thus, it can be suggested that the result has a great application in the ferromagnetic hyperthermia.