α_1型基因工程干扰素治疗带状疱疹

CLINICAL OBSERVATION OF RECOMBINANT ALPHA-1-INTERFERON IN THE TREATMENT OF HERPES ZOSTER

观察４２例每日肌注α＿１型基因工程干扰素１００万单位连续６ｄ治疗带状疱疹的疗效，并和３４例口服无环鸟苷２００ｍｇ，５次／ｄ，共７ｄ以及４８例常规维生素Ｂ＿（１２）、Ｂ＿１和Ｂ＿２疗法作对比。结果显示干扰素组、无环鸟苷组对比维生素组，在缩短病程和控制症状有明显差异（ｐ＜０．０１）。

Patients with herpes zoster were divided into 3 groups.The first group was treated with i.m,recombinant alpha-1-interferon(IFN)in a once daily dose of one mil- lion unit for 6 days in 42 cases. The second group was treated with oral acyclovir(ACV)in a dose of 200 mg 5 times daily for 7 days in 34 cases.The third group was treated with vi-tamin B12,B1 and B2 in conventional dOse for 7～14 days in 48 cases. Results showed that the total duration of symptoms of herpes zoster can be shortened by both IFN and ACV in comparision with vitamin therapy(P<0.01)。