摘要
为了探讨木尘与癌症的关系,我们对某木综厂进行了回顾性队列研究,木尘组为该厂接触木尘者2362(男1707,女655)人,33679人年,观察期15年(1978.1.1.~1992.12.31.),非木尘组为本地某煤矿职工2587人,54040人年,观察期21年(1972.1.1.~1992.12.31.),并与当地居民的死亡率进行了比较。队列中全部癌症病人均为I~Ⅱ级诊断,木尘接触工人前3位的癌症分别是肺癌(35.1%)、肝癌(18.2%)和食道癌(15.6%)。与非木尘组比较,木尘接触职工全癌、肺癌、肠癌、食道癌的标化死亡率分别为242.52、74.62、43.78和42.82/10万,RR分别为1.98、4.08、3.23和2.88,均有高度显著性差异(P<0.01)。全癌、肺癌、肠癌和白血病的SMR分别为154.8、218.6、284.8和352.7(P<0.05或P<0.01)。提示木尘可能与肺癌、肠癌、食道癌、肝癌和白血病有一定关系。
A retrospective cohort study was conducted from Jan.1.1978 through Dec.31.1992 for exploring the relationship between wood dust exposure and cancer.2362 woodworkers(33679 person-years)employed by the wood processing factory in Chengdu,China,before 1977 as exposure group.2587coal workers(54040 person-years)employed by a native coal mine in the same area before 1971 as control group.The first three most common cancers for woodworkers were lung cancer(35.1%),liver cancer(18.2%)and esophagus cancer(15.6%).Comparing with control group,there were obviously elevated stardardized mortality rates,such as 242.52/105(RR1.98,P<0,01)for all cancers(ICD9,44~208),74.62/105(RR4.08,P<0.01) for lung cancer(ICD 9,162),43.78/105(RR3.32,P<0.01)for intestine cancer(ICD 9,152~154)and 42.82/105(RR2.88 ,P<0. 01) for esophagus cancer(ICD 9,150).Comparing with the mortality rates in local residents the stardardized mortality ratios(SMR)respectively were 154.8/105(P<0. 05)for all cancer,218.6/105(P<0. 01)for lung cancer,284.8/105(P<0.05)for intestine cancer and 352.7/105(P<0.05)for leukemia.The stardardized mortality rates and SMR didn’t show significant increases for other cancers.
出处
《中国工业医学杂志》
CAS
1996年第1期5-9,共5页
Chinese Journal of Industrial Medicine
关键词
木尘
癌症
队列研究
wood dust,cancer,cohort study