柠檬酸铝和羟基喹哌联合治疗尘肺的临床观察

Clincal observations on Combined Treatment with Aluminum Citrate and Hydroxypiperaquine Phosphate in Pneumoconiosis

采用柠檬酸铝和羟基磷酸喹哌联合治疗９１例尘肺病人（对照４４例），通过６个疗程两年半的对比观察，证明治疗组的症状改善优于对照组，有５例（５．５％）胸部Ｘ线表现明显好转或好转，而对照组无好转病例，且进展例数多于前者，差异有显著性（Ｐ＜０．０１）。治疗期间未发现明显的毒副作用，说明柠檬酸铝和羟基磷酸喹哌长期联合治疗是安全有效的。

pneumoconiosis cases were treated with Aluminum Citrate and Hydroxypiperaquine Phosphate for two and half years.After 6 courses the improvement of clinical symptoms in the treated group was greater than that in the control group(44 pheumocomiosis patients).The radiological improvement was shown in the Chest X-ray films of 5 cases(5.5%),but was not found int he controls.Furthermore,the progresive cases in controls were much more than those in the treated group(P<0.01).There was no significant side effect during treatment.The results indicate that the combined treatment with Aluminum Citrate(20mg Al/week)and Hydroxypiperaquine Phosphate(0.5g/week)was effective and safe.