胸水间皮细胞计数对良、恶性胸腔积液的鉴别诊断

Countin of PMC in pleural fluid:A valuable method to idetnify benign and malignant hydrothorax

目的观察胸水间皮细胞计数对良、恶性胸腔积液鉴别诊断的价值。方法收集2000年12月-2005年6月胭胸腔积液住院患者188例的胸水常规间皮细胞计数。结果良性胸水间皮细胞计数为3.09±1.78%;恶性胸水间皮细胞计数为6.98±2.34%,两者有统计学差异(P<0.01)。良、恶性胸水间皮细胞计数95%可信区间分别为1.76～5.02%和5.09～8.87%,以胸液中间皮细胞计数大于5%作为诊断恶性胸腔积液的标准,其敏感性为93.5%,特异性为90.9%。结论胸水间皮细胞计数对良、恶性胸腔积液的鉴别诊断有较高的敏感性和特异性,且方法简单、快捷、经济,值得临床常规应用。

Objective Counting of PMC（pleural mesothelial cell ）in pleural fluid is reported to be useful for differential diagnosis of bening and malignant hydrothorax. Methods 188 patients with hydrothorax were recrutied for the study,which were hospitalized during Dec, 2000 and JuI. 2005. Results In patients with benign and malignant hydrothorax,PMC level in pleuraI fluid were 3.09%± 1. 78 %, and 6. 98 %± 2.34%, respectively. The latter was significantly higher than the former, P ≤ 0. 01. The confidence interval of PMC counting in benign pleuraI fluid was 1.76%-5.02% and 5.09%-8. 87% in malignant pleuraI fluid. We defined that if PMC level in pleuraI fluid was more than 5%othe diagnosis was malignant hydrothorax, sensitivity of the diagnosis was 93.5 % ,and specificity was 90. 9 %. Conclusion PMC counting appears to be sensitive and specific to identify benign and malignant hydrothorax,and moreover,it is simple,fast and economical. Therefore,we consider that it can be routinely used.