肺炎衣原体感染与急性脑梗死的相关性

The Correlation between Chlamydia Pneumonia Infection and Acute Cerebral Infarction

目的:探讨肺炎衣原体(Cpn)感染与急性脑梗死发生发展的关系。方法:采用微量免疫荧光法(M IF)检测100例急性脑梗死患者(病例组)与100例同期门诊健康体检者(对照组)肺炎衣原体血清特异性IgG、IgM抗体,并使用全自动生化仪检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)浓度及C-反应蛋白(CRP)水平。结果:病例组和对照组肺炎衣原体慢性感染率分别为72.0%、50.0%,差异有显著性(P<0.01)。急性感染率分别为15.0%、12.0%,两组差异无显著性(P>0.05)。病例组血脂水平:TC(6.1±1.48)mm o l/L,TG(2.69±1.91)mm o l/L,LDL-C(3.85±0.25)mm o l/L,HDL-C(1.03±0.56)mm o l/L;对照组TC、TG、LDL-C、HDL-C水平分别为(4.22±0.43)mm o l/L,(1.08±0.25)mm o l/L,(2.48±0.65)mm o l/L,(1.15±0.59)mm o l/L;两组CRP水平分别为:(13.72±5.30)m g/L,(5.61±2.4)m g/L;两组在血脂、CRP水平比较差异有显著性(P<0.01)。在病例组中,肺炎衣原体阳性者(感染组)血清TC、TG浓度及CRP水平高于阴性者(非感染组)(P<0.05),HDL-C浓度略低于非感染组,但差异无显著性(P>0.05)。结论:肺炎衣原体慢性感染与脑梗死发病有一定的相关性,血清中的CRP和肺炎衣原体抗体水平升高提示炎症反应增强。

Objective：To explore the relationship between chlamydia pneumonia infection and acute cerebral infarction. Methods. Chlamydia pneumonia-specific IgG and IgM antibodies were measured by Microimmunofluorescence （MIF） in groups of 100 healthy patients and 100 patients with acute cerebral infarction. Serum concentrations of total cholesterol （TC）, triglyceride （TG）, low density lipoprotein-cholesterol （LDL-C）, high density lipoprotcin-cholesterol （HDLC） and level of C-reactive protein （CRP）were detected by automatic biochemistry analyzer. Results：The chronic chlamydia pneumonia infection rates were 72.0% and 50. 0% ,respectively,in crecbral infarction group and control group with significant difference （P〈0. 01 ）. The acute infection rates were 15.0% and 12.0% ,respectively ,in the two groups without significant difference （P〉 0. 05）. There were significant difference in the levels of TG, TC,CRP between crecbral infarction group and control group （P〈0.01）. TC,TG,CRP levels in CpnIgG postitive cases were obviously higher than those in IgG negative cases（P〈0. 05）,hut there was no significant difference in HDL-C level （P〉0. 05）. Conclusions：The chronic chlamydia pneumonia infection has certain correlation with the cerebral infarction. Higher CpnIgG antibody titers and higher serum CRP level indicated that the response to the inflammation were strengthened.