摘要
对40例重症肺感染患者血清肿瘤坏死因子(TNF)水平进行放免测定,并与40例正常人进行对照。结果显示:肺感染患者血清TNF处于高水平状态,与正常人相比有极显著性差异(P<0.001);10例患者治疗2周后血清TNF水平较治疗前明显降低(P<0.05)。提示肺感染时机体释放过量的TNF,参与炎症所致的急性肺损伤过程;血清中TNF水平能反映肺部感染状态及病情变化。作者认为:对血清TNF水平,特别是对肺泡灌洗液中TNF含量变化及其与其它细胞因子相互作用的研究。
Serum tumor necrosis factor(TNF) was assayed in 40 patients with severe lung infection,and compaired with that in 40 normal controls.We found that :serum TNF level in patients with lung infection was much higher than that in normal controls( P <0 001);it decreased significantly in 10 patients after two weeks treatment( P <0 05).It is suggested that excessive TNF is released in lung infection patients,involving in acute lung injury process caused by inflammation.Serum TNF may well reflect the severity of lung infection.
出处
《中国危重病急救医学》
CAS
CSCD
1996年第4期220-221,共2页
Chinese Critical Care Medicine
关键词
感染
肺部
肿瘤坏死因子
血清
lung infection
serum tumor necrosis factor