重症肺感染患者血清肿瘤坏死因子水平的变化

Serum tumor necrosis factor level in patients with severe lung infection

对４０例重症肺感染患者血清肿瘤坏死因子（ＴＮＦ）水平进行放免测定，并与４０例正常人进行对照。结果显示：肺感染患者血清ＴＮＦ处于高水平状态，与正常人相比有极显著性差异（Ｐ＜０．００１）；１０例患者治疗２周后血清ＴＮＦ水平较治疗前明显降低（Ｐ＜０．０５）。提示肺感染时机体释放过量的ＴＮＦ，参与炎症所致的急性肺损伤过程；血清中ＴＮＦ水平能反映肺部感染状态及病情变化。作者认为：对血清ＴＮＦ水平，特别是对肺泡灌洗液中ＴＮＦ含量变化及其与其它细胞因子相互作用的研究。

Serum tumor necrosis factor(TNF) was assayed in 40 patients with severe lung infection,and compaired with that in 40 normal controls.We found that :serum TNF level in patients with lung infection was much higher than that in normal controls( P <0 001);it decreased significantly in 10 patients after two weeks treatment( P <0 05).It is suggested that excessive TNF is released in lung infection patients,involving in acute lung injury process caused by inflammation.Serum TNF may well reflect the severity of lung infection.