小儿呼吸衰竭时血循环内皮细胞检测及其意义

Level of circulating endothelial cells in children with respiratory failure

检测１６例呼吸衰竭（呼衰）患儿血中循环内皮细胞（ＣＥＣ）含量。结果：呼衰急性期ＣＥＣ为（１１．８１±０．２２）×１０６／Ｌ，恢复期为（５．１７±１．４０）×１０６／Ｌ，正常对照组为（４．１０±１．０９）×１０６／Ｌ，急性期与恢复期及对照组比较均有显著性差别（Ｐ均＜０．０１）。作者认为血管内皮细胞（ＶＥＣ）损伤参与了呼衰的发生发展；ＣＥＣ可作为呼衰治疗效果及预后判断的预警信号；进一步探索保护、稳定肺ＶＥＣ免遭致病因子损伤的药物。

The circulating endothelial cells (CEC) of 15 healthy children and 16 patients with respiratory failure were counted respectively.CEC count of the patients in acute stage (11 81±0 22)×10 6/L was more than that of the healthy children (4 10±1 09)×10 6/L and the patients in convalescence (5 17±1 40)×10 6/L, P <0 01 .It suggests that the change of CEC count may be useful for evaluating the effects of the treatment and the prognosis of respiratory failure.