被动吸烟对小鼠子代细胞遗传效应的研究

THE CYTOGENETIC EFFECT ABOUT SECOND HAND SMOKING ON MICE OFFSPRING.

本文根据动物实验模型设计,以姊妹染色单体交换、微核细胞率和染色体畸变率为指标,研究了被动吸烟对小鼠子代的细胞遗传学损伤。昆明处女鼠与雄鼠交配后随机分为6组,每组5—7只孕鼠,于孕期5—15d分别以4.79/m^3、9.49/m^3、14.19/m^3和18.89/m^3四个浓度剂量被动吸烟。结果表明,染色体畸变率和微核细胞率随被动吸烟的浓度增高而增加,并且两者的变化速率呈正相关。SCE的频率与随之增高,证实了香烟烟雾对小鼠子代的遗传毒理效应是显著的。

In this paper,the cytogenetic effects of second hand smoking on mice offspring were investigated by ar animal experimental model. Virgin Kunming mice were mated and divided randomly into six groups with 5—7 pregnant mice in each group. During the 5-15d of gestation,the mice were exposed to smoke in conceritrations of 4.7g/m^3, 9.4g/m^3, 14.1g/m^3,and 18.8g/m^3. The results showed that the frequencies of chromosome aberrations(CA) and micronuclei(MN)increased with increasing dosge of smoke,and both were positive correlations. The frequencies of SCE also increased. The significant genetic toxic effect of the cigarette smoke was confirmed.