摘要
采用放射免疫分析法测定了21例非肥胖正常人,24例肥胖患者及20例糖尿病患者血浆肥胖蛋白[OP-(57-92)]水平。结果显示;肥胖患者血浆肥胖蛋白水平(109.1±16.4pg/ml)及糖尿病患者血浆肥胖蛋白水平(81.0±17.5pg/ml)均显著低于非肥胖正常人(194.3±17.7pg/ml)。非肥胖正常人及肥胖患者血浆肥胖蛋白水平与体重指数、血糖、胆固醇及甘油三脂呈显著负相关,表明人肥胖蛋白在调节体重及内分泌代谢方面具有非常重要的作用。
Plasma obese gene(OG) product [OP-(57-92)] level was measured with ra-dioimmunoassay in 21 normal subjects ,24 adult obese patients and 20 patients with type I diabetes (DM I ).The results showed that plasma obese protein (OP) levels in normal subjects (194.3±17.7pg/ml) were significantly higher than those in other groups (P<0. 01) , There was significantly negative correlation between serum OP level and body weight index , blood glucose cholesterol and triglycerides. These data suggest that OP should be important in the regulation of body weight and endocrine function.
关键词
肥胖
糖尿病
肥胖蛋白
obese
diabetes mellitus
obese protein
