^(3)H─TdR体内滞留诱发生殖毒性研究

THE METABOLICCHARACTERISTICSOF3H-TdRINORGAN-ISMONINDUCTIONOFREPRODUCTIONTOXICITY

研究了摄入氚标记胸腺嘧啶核苷（^(３)Ｈ－ＴｄＲ）在机体滞留过程诱发的生殖毒性效应。拟合了^(３)Ｈ－ＴｄＲ在睾丸、肝、脾、肾、股骨和血活中的滞留方程通式为：Ｒ（ｔ）＝Ａｅ－λａｔ＋Ｂｅ－λβｔ。比较了在不同组织的快组份和慢组份的有效半减期，估算了在不同脏器部位的累积吸收剂量。^(３)Ｈ－ＴｄＲ可诱发雄性生殖细胞的生殖毒性，表现为显性致死突变和显性骨骼畸形。关于显性致死突变与摄入了^(３)Ｈ－ＴｄＲ放射性活度之间呈正相关。Ｙ＝８０ . ２０Ｉ＋７４．１３；而显性骨骼畸形享与摄入^(３)Ｈ－ＴｄＲ放射性活度间的关系式为：Ｂ＝０．０７９１＋０．１６。

This paper reports the accumulation of ￣(3)H-TdR in organism on induction of germtoxicity. The data of retention of 3H-TdR in testes,liver,spleen,kidney,femur and bloodwere described by an usually exponential expression:R(t)=Ae-λat+Be-λβt.Where the reten- tion T1/2 in various tissues and the cumulative absorbed dose- estimation of3H- TdR in vari- ous organs were compared respectively.￣(3)H- TdR could damage genetic materials and causedominant lethality and the skeletal abnormalities in offsprings. The relationship between thedominant lethal mutation(Y)and the injected activity of￣(3)H-TdR(I)was Y=74.13+80. 20I.While the relationship betwcen the incidence of the dominant skeletal abnormalities inoffsprings(B)and the accumulatcd radioactivities of3H-TdR(I)in testes wasB=0.16+0. 79I.