摘要
本文用组合试验评价酸角的致夹变性。结果表明：酸角在Ａｍｅｓ、小鼠骨髓细胞微核和精子畸形、枯草杆菌ＤＮＡ修复试验及大肠杆菌ＷＰ２和ＷＰ２ＵＶｒＡ苗株中均为阴性反应；在大肠杆菌ＭＲ２－１０２和ＮＤ１６０菌株中为阳性反应，是酸角中的乳糖所致；ＳＣＥ频率随酸角剂量增加而稍有降低，与对照组比有显著性差异（Ｐ＜０．０５），揭示酸角可能有抗ＤＮＡ损伤作用。
The mutagenicity of Tamarind was evaluated with a battery of mutation tests. Themutagenicity of Tamarind showed negative results in Ames,bone marrow micronucleus andsperm aberration in mice,B. subtilin DVA rcpair tests and E,coli WP2 and WP2uvrAstrains。In E. coli MR2-102 and ND160 strain:showed positive response,which was causedby the lactose content in the Tamarind.The SCE frequencies decreased slightly with the in-crease of Tamarind dose,which has significant differences as compared with control(P<0. 05),and tentatively suppose that Tamarind has effects of anti- DNA-damage.
出处
《癌变．畸变．突变》
CAS
CSCD
1996年第2期91-94,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
酸角
基因突变
微核
精子畸形
Tamarind
Gene mutation
Micronucleus
Sperm teratism
sister chromatid ex-change
