摘要
采用大肠杆菌PQ37的SOS显色法和TA100、TA98菌株的Ames试验检测动物碑组织浸液的遗传毒性。在两个测试系统中均呈阴性反应;用SOS显色法测定浸液对茶陡酮酸、丝裂霉素C所诱导的SOS应答以及Ames试验测定浸液对由叠氮钠、敌克松所诱发的回变作用,有一定的抑制作用(P<0.01),其强度与浸液浓度呈正相关。
The genotoxin and antimutation of spleen tissue extracts were detected by theAmes and SOS colorimetric test. Salmonells typhimurium TA98,TA100 were selected as theAmes tester strain. Escherichia coli k 12 PQ37 was used in the SOS chromotest.Both of themwithout S9 mix.Negative responses were showed in two systems. When spleen tissue ex- tracts were incubuted with NaN3,Dexson,MMC and Nalidixic respectively,the mutagenic po- tency whether in Ames or SOS test all had a significantly decrease.(P<0.01)。
出处
《癌变.畸变.突变》
CAS
CSCD
1996年第2期103-106,共4页
Carcinogenesis,Teratogenesis & Mutagenesis