早期胃癌直径、淋巴结转移与组织VEGF、MMP-7表达强度的相关性

Clinical study of relationship between diameter of early gastric cancer as well as lymph node metastasis and expression of VEGF and MMP-7

目的研究早期胃癌的直径、淋巴结转移与血管内皮生长因子(VEGF)、基质金属蛋白酶-7(MMP-7)表达的相关性。方法55例早期胃癌患者经黏膜颜色、活检及术后病理证实。用免疫组织化学法检测VEGF、MMP-7的表达强度。结果直径小于10mm的早期胃癌病人的癌组织的VEGF、MMP-7表达水平明显低于10mm≤直径≤20mm的早期胃癌的组织水平(P<0.05),直径>20mm的早期胃癌病人的VEGF、MMP-7的表达明显高于10mm≤直径≤20mm的病例的表达,且与胃癌的组织分型明显相关(P<0.001),但与早期胃癌的浸润深度不相关(P>0.05)。结论早期胃癌瘤体直径的大小与VEGF、MMP-7表达强度相关,VEGF和MMP-7表达均阳性的病例淋巴结转移率高。

Objective To investigate the relationship between diameter of early gastric cancer as well as lymph node metastasis and expression of vascular endothelial growth factor（VEGF） and Matrix metalloproteinases - 7 （MMP - 7） in gastric cancer. Method VEGF and MMP - 7 expressions of gastric cancer tissue in 55 cases were examined by immumohistochemical assay. The diagnosis was confinned by mucous stain and pathology. Results The level of VEGF and MMP- 7 expression in group of early gastric cancer with diameter ≤ 10 mm was significantly lower than that of diameter ≥ 10 mm and ≤ 20 mm （P〈0.05）. The level of VEGF and MMP-7 expression in group with diameter≥ 20 mm was significantly higher than that of diameter≥10 mm and ≤ 20 mm（ P 〈 0.05）. The expression of VEGF and MMP - 7 were significantly associated with differentiated tissue type of early gastric cancer （P〈0. 001） and lymph node metastasis, and had no relation with the invasive depth of early gastric cancer （P〉0.05）. Conclusion It is significant that relation of the diameter of early gastric cancer with VEGF and MMP-7 expression, the cases of strongly positive over- expression of both VEGF and MMP- 7 in tissue of patients with early gastric cancer are accompanied by more likelihood of lymph node metastasis.