孕产妇血清叶酸分布特点及胎儿神经管缺损与母亲血清叶酸关系的研究

A STUDY OF THE DISTRIBUTION OF FOLIC ACID IN PREGNANT WOMEN AND THE ASSOCIATION BETWEEN NEURAL TUBE DEFECTS AND MATERNAL FOLIC ACID

1985～1987年在北京地区进行了孕产妇血清叶酸分布特点及与胎儿神经管缺损关系的研究,结果显示:正常孕妇血清叶酸水平随孕周增加逐渐下降,且冬季最低,秋季最高,农村低浓度叶酸所占比重远高于城市。44例神经管缺损儿母亲的血清叶酸略低于88例正常儿对照母亲。病例对照研究结果表明,母亲血清叶酸水平低下,极少食水果、膳食质量差和女性胎儿可能是胎儿发生神经管缺损的危险因子。

The study consisted of two parts: (1) Various distribution of folic acid (FA) levels in pregnantwomen, and (2) 1:2 case-control study of neural tube defects (NTD) with emphasis on FA, wascarried out from December, 1985 to February, 1987 in Beijing, where NTD was prevalent. The serumFA was analyzed with ^(125)I radio-immuno-assay. It was observed that there were various distributions of FA in pregancy progresses, seasons, andplaces. Lower mean serum FA concentraton was found in 44 mothers of NTD offspring (3.72±1.43ng/ml) as compared with 88 control mothers (4.57±3.69ng/ml) (one-tail test P<0.05). Case-control study showed four risk factors for NTD: (1) Maternal serum FA level in thirdtrimester lower than 2.8ng/ml. (2) Female baby. (3) Very rarely eating fruits in late pregnant period.And (4) Poor diet.