二甘氨酰组氨酸铜催化抗坏血酸氧化产生的活性氧自由基对DNA的断裂作用

DNA BREAKING EFFECT OF Cu(Ⅱ):GLYCYLGLYCYLHISTIDINE AND VITAMIN C SYSTEM

[Cu(Ⅱ):GGH+Vc]体系可断裂DNA,断裂作用与Cu(Ⅱ):GGH及Vc的浓度成正比,HO·捕获剂阻化DNA断裂,证实了Vc体系的防癌作用与其氧化过程中产生的HO·有关。

Cu(Ⅱ): GGH and Vc system can strongly break DNA. The breaking effect is proportional toboth Cu(Ⅱ): GGH and Vc concentrations. HO·captures can inhibit the breaking of DNA. It mean,the breaking of DNA is caused by HO·This demonstrates that the antitumor effect of Vc is related tothe reactive oxygen radicals that are produced in the process of the catalytic reaction of Vc.