仿生增强制备聚乳酸基骨组织工程复合材料

Biomimetic Strengthening PLA Scaffold Materials for Bone Tissue Engineering

依据仿生原理制备了纳米羟基磷灰石聚乳酸(nHA-PLA)复合的骨框架材料.此复合材料中的主要成分是纳米羟基磷灰石,纳米相的羟基磷灰石就是天然骨中主要的无机相.在保持高孔隙率(90%)的同时,复合材料的抗压性能达到2.07 MPa,高于单纯的聚乳酸框架材料(为0.89 MPa).分离成骨细胞并在三维框架材料上培养,用扫描电镜进行观察,复合材料具有很好的细胞贴附性能.仿生制备的三维纳米羟基磷灰石聚乳酸复合骨框架材料,无论从结构还是性能上,都是骨组织工程中的优选材料之一.

We designed a new Polylactide（PLA） based scaffold composite by biomimetic synthesis. The new composite mainly consisted of nano-hydroxyapatite n-HA, which is the main inorganic content in natural bone tissue for the PLA. The crystal degree of the n-HA in the composite was low and the crystal size was very small, which was similar to that of natural bone. The compressive strength of the composite was higher than the PLA scaffold. Using osteoblast culture technique, the ceils behavior on the biomaterial in vitro was detected by SEM. The higher cell affinity on the comtxxsite than the PLA scaffold was shown. The biomimetic three-dimensional porous composite can serve as an excellent scaffold material for bone tissue engineering both in terms of microstructure and properties.