生长抑素与遗传性惊厥易感性

SOMATOSTATIN AND GENETIC SEIZURE SUSCEPTIBILITY

本文以遗传性听源性惊厥易感的P_(77)PMC大鼠为动物模型,研究了生长抑素(Somatostati-n,SS)在遗传性惊厥易感性发生中的可能作用。结果显示,P_(77)PMC大鼠大脑皮层和海马中的SS含量明显高于对照组。SS的特异性耗竭剂半胱胺可抑制P_(77)PMC鼠的听源性惊厥发作。10^(-5)～10^(-8)mol/L的SS对体外培养的大鼠大脑皮层神经细胞的r-氨基丁酚(GABA)释放有明显抑制作用。说明生长抑素在遗传性惊厥的发生中起一定作用。

We studicd the relationship between SS and Genetic Seizure Susceptibility using P 77PMC rat strainwhich is genetically susceptible to audiogenic seizure. In vivo study we found that Cystmine, adepletive medicine of endogenic SS, can inhibit the attack of audiogenic seizure of P 77 PMC rats.Using RIA we found that the contents of endogenic SS in both cerebral cortex and hippocampus ofP 77 PMC rats are significantly higher than that in control rats. Utilizing primary cultures ofdevelopmental cerebral cortical neurons of 16-day fetuses of rats, we found the GABA release rate fromcerebral cortical neurons could be much stronger inhibited by SS with the concentration ranging from10^(-5) to 10^(-8) mol/l in P 77 PMC. We presume that SS is related to the Genetic Seizure Susceptibility