胎儿和新生儿前列腺生长发育

GROWTH AND DEVELOPMENT OF FETAL AND NEWBORN PROSTATE

对107例胎儿和新生儿尸检前列腺标本进行组织形态和组织化学研究。胎儿前列腺生长发育可分为三个阶段,即芽突期、芽管期和腺管期。腺体分泌活动以侧叶区最著,前叶区次之,后叶区最弱。上皮有不同程度鳞状上皮化生。新生儿与妊娠后期胎儿前列腺无明显差别。

Microscopic studies were perflormed on whole, cross-sectioned prostates harvested from 107 necro-psies of fetuses and newborns, ages langing from 20 weeks gestation to one month. Sections werestained with H&E, PAS, Alcian Blue, Van Grieson, Trichrome, and Immunopeeroxidase for prostatespeeific antigen (PSA). The observed histologic and histochemical changes accompanying prostaste growth and davelopmentin the fetus and newborn suggestsed an 'asynchronour' growth patten. The development of prostategland tissues could be recognized as occurring in three separate stages: bud stage (20-30 weeks gesta-tion), bud-butule stage (31-36 weeks gestation), and acinotubular stage (37-42 weeks gestation). Onepattern of prostate development was quite similar to that described in the adult as the budding typeof 'atypical hyperplasia'. PAS and alcian blue- PAS positive secretions were present in 65 prcent ofthe specimens by 20 to 30 week gestation and in over 87 percent of the specimens by 37 or more weeksgestation. Secretory activity was most prominent in the lateral regions of the peripheral zone. PSAstaining was weakly positive throvghout the prenatal deriod; PSA staining was not ralatad to secrdtoryactivity as evidenced by the PAS technigue. In many cases, squamous metaplasia appeared in the urethra,utricle, and primery lobular ducts. Occasionally, microsysts were noted.