自发性高血压大鼠心脏α_1肾上腺素受体及其亚型的改变

CHANGES OF CARDIAC α_1-ADRENOCEPTOR AND ITS SUBTYPES IN SPONTANEOUSLY HYPERTENSIVE RATS

采用放射性配体结合方法测定与比较WKY与易卒中型自发性高血压SP大鼠心室组织中α_1肾上腺素受体(α_1受体)及其亚型的数量与亲和性。结果显示,SP大鼠心室组织中总的α_1受体的数量及对^(125)Ⅰ-BE的亲和性与对照WKY大鼠无显著差别。WKY大鼠心室组织中的α_1 受体包含α_(1a)与α_(1b)两种亚型,而SP大鼠仅含α_(1b)一种亚型。

The quantities and the affinities of cardiac α_1-adrenoceptor and its subtypes were measured andcompared between WKY and stroke prone spontaneously hypertensive (SP) rats by the method of radioligand binding. The results showed that there were no differences in the total numbers and the affini-ties for ^(125)I-BE between SP and WKY rat heart tissues. There were two subtypes-α_(1a) and α_(1b) in hearttissues of WKY rats, but only one subtype-α_(1b) in heart tissues of SP rats.