不动杆菌对临床常用抗菌药物耐药性及耐药机制分析

Resistant mechanisms and drug resistance of Acinetobacter to commonly used antimicrobial agents

目的了解不动杆菌对常用抗菌药物耐药性及产生机制。方法应用回顾性调查分析方法对临床标本中分离的150株不动杆菌的药敏试验结果进行统计分析。结果不动杆菌对亚胺培南、哌拉西林/三唑巴坦耐药率在11.3%以下,而头孢噻肟、氨苄西林、头孢呋辛、头孢西丁、头孢唑林、头孢噻吩耐药严重,耐药率在74.0%～89.3%之间,其余抗菌药物耐药率在23.3%～46.7%之间。35株不动杆菌产超广谱β-内酰胺酶,阳性率为23.3%,52株产Am pC酶,阳性率为34.7%。结论不动杆菌对常用抗菌药物有不同程度的耐药,产生β-内酰胺酶为主要耐药机制,根据药敏试验结果合理用药,对提高感染治愈率及减缓多重耐药菌株的出现有重大意义。

Objective To investigate resistant mechanisms and drug resistance of Acinetobacter to commonlyused antimicrobial agents. Methods The drug resistance of Acinetobacter isolated from clinical samples was studied retrospectively. Results The drug resistance to imipenem and piperacillin/tazobactam was less than 11.3%. To cefotaxime, ampicillin, cefuroxime, cefoxitin, cefazolin, cephalothin was between 74. 0% - 89.3% , others were between 23.3%-46. 7%. The positive rate of extended-spectrum beta-laetamases and AmpC enzyme were 23.3% and 34. 7%, respectively. Conclusions All Acinetobacter strains have drug resistance in some degree. The resistance of Acinetobacter was mainly due to production of broad spectrum beta-lactamase. It is very important to select antibiotics correctly for increasing the cure rate and controlling drug resistance.