CD105在骨巨细胞瘤中的表达及其意义

Expression and Significance of CD105 in Giant Cell Tumor of Bone

目的研究CD105在骨巨细胞瘤组织中的表达及CD105标记的微血管密度与骨巨细胞瘤生物学行为的关系。方法采用S-P免疫组织化学染色法,用CD105单抗标记并检测38例骨巨细胞瘤中的微血管密度。结果骨巨细胞瘤组织学分级Ⅰ级与Ⅱ级、Ⅰ级与Ⅲ级、Ⅱ级与Ⅲ级间,其MVD值的差异无显著性(P>0.05)。而肿瘤内微血管密度(Micro Vessel Density,MVD)值与放射学分级相关。浸润型肿瘤的MVD值明显高于静止型,差异有显著性(P<0.05)。复发组的骨巨细胞瘤其MVD值高于未复发组,差异有极显著性(P<0.01)。结论CD105标记的MVD值与组织学分级无关,与放射学分级和肿瘤复发有关,CD105标记的MVD可作为预测骨巨细胞瘤复发的客观依据。

Objective To study the expression level of CD105 in giant cell tumor in the bone and detect the correlation between MVD counted with CD105 and the biological behavior of the tumor. Methods MVD in 38 cases of giant cell tumor in the bone were marked with CD105 by using SP immunohistochemical method. Results The average MVD in giant cell tumor of bone was 9.70 ± 2.34. No significant difference was found among pathology grade Ⅰ , Ⅱ and Ⅲ cases（ P 〉0.05）, while there was significant difference between radiological grade Ⅲ and grade Ⅰ cases （P〈0.05）. Recurrent cases had higher MVD than in the cases without recurrence（P〈0.01）. Conclusions MVD counted with CD105 is strongly related to its radiological grade and tumor recurrence. MVD marked by CD105 can be used as possible prognostic indication of tumor recurrence.