不同剂量达虫净对山羊自然感染线虫的驱虫效果试验

Dosage Effect of Fenbendazole on Expelling Nematodes in Naturally Infected Goat

按体重5mg/kg、10mg/kg、15mg/kg不同剂量的达虫净对自然感染线虫的山羊进行拌料饲喂驱虫,同时用0.2mg/kg阿维菌素一次皮下注射作药效对照,并设空白对照组。分别于用药前及用药后第7天取粪便进行虫卵计数。用药后第2天起每天检查由粪便中驱出的虫体数至查不出为止。结果表明:各剂量组药物对肺线虫虫卵减少率分别为100%,100%,100%,83.3%,虫卵转阴率分别为100%,100%,100%,66.7%;对捻转血矛线虫等其他线虫虫卵减少率分别为88.9%,100%,100%,100%,虫卵转阴率分别为66.7%,100%,100%,100%。用药后第2天病羊开始排虫,第3天为排虫高峰,第4天排虫减少,第5天仅见有少量虫体,第6天以后未再见虫体排出。

Fifteen pregnant Nemathelminth - infecting goats averaging 2 - 3 years of age were randomly divided into 5 groups. Ⅰ - Ⅲ groups were fed with Fenbendazole （Dachongjing） at a dosage of 5mg/kg. bw, 10 mg/kg, bw and 15 mg/kg, bw just for once, respectively, the IV group injected subcutaneously with Avermectin at a dosage of 0.2 mg/kg, bw and the V group with no treatment were used as the control. The worms and eggs were counted everyday after treatment till no one was found in feces. The results showed that, after orally administrating Dachongjing, the infected goats could be cured completely by using the dosage of 10 mg/kg, bw or 15 mg/kg, bw; nematodes were discharged on the second day, the number of worm- excreted summit appeared on the third day and then began to drop down on the fourth day, only a few were found out on the fifth day and none could be found on the sixth day. The curative effect of Dachongjing was better then that of Avermectin.