全反式维甲酸治疗乙双吗啉所致急性早幼粒细胞白血病14例

TREATMENT OF 14 CASES OF ACUTE PROMYELOCYTIC LEUKEMIA CAUSED BY BIMOLANE WITH ALL TRANS RETINOIC ACID

应用全反式维甲酸治疗乙双吗啉所致急性早幼粒细胞白血病１４例，当出现高白细胞综合征时联用小剂量阿糖胞苷。结果１２例完全缓解，染色体移位消失，占８５．７％，２例早期死于脑出血。达完全缓解所需时间为２１天～６３天（平均２７．５天），所需全反式维甲酸总量为１２６０ｍｇ～３９２０ｍｇ（平均１７７４ｍｇ）。到１９９３年１０月止，完全缓解后无１例复发，持续完全缓解时间已达２～５４个月（平均２１．５月）

cases of acute promyelocytic leukemia eaused by bimolane was treated by all trans retinoic acid. While leukocytosis appeared, a low dose of cytosine arabinoside was used to treat the disease with all trans retinoic acid. Among the 14 patients, 12 cases obtained complete remission(85.7%), and chromosome translocation reverted to normal karytype after 21～63 days (mean 28 days), and 2 cases died of cerebral hemorrhage in early stage(14.2%). Total dosage of all trans retinoic acid used in obtaining complete remission was 1260～3920 mg (mean 1774 mg). By October 1993, the duration of complete remission was 2～54 months (mean 21.5 months). None of the patients with complete remission had relapsed.