ERα、ERβ、pS2蛋白在子宫平滑肌肉瘤组织中的表达及意义

Expression of ER-α,ER-β,pS2 in uterine leiomyosarcoma

目的 研究ERα、ERβ、pS2蛋白在子宫平滑肌肉瘤组织中的表达及意义。方法 选取1997年1月～2004年5月闻，青岛大学医学院，青岛市第三人民医院，第八人民医院，收治的子宫肌瘤和平滑肌肉瘤患者128例的石蜡块，用免疫组化法测定ERα、ERβ、pS2表达。结果 子宫平滑肌肉瘤中，ERα阳性率（36.1％），子宫肌瘤中ERα阳性率（83．6％），两者比较有显著性差异（P〈0．01）；其强度亦有显著性差异（P〈0．01）；平滑肌肉瘤ERβ阳性率（18．0％）子宫肌瘤中ERβ阳性率（59、7％），两者比较有显著性差异（P〈0．01）；其强度亦有显著性差异（P〈0.01）。平滑肌肉瘤pS2阳性率（41．0％）子宫肌瘤pS2率（23、9％），两者比较有显著性差异（P〈0.05）；pS2在子宫平滑肌肉瘤中的表达强度比在子宫肌瘤中高，两者比较有显著性差异（P〈0.05）。随着子宫肉瘤临床分期的增加，ERα、pS2的阳性表达率降低，差异有显著性（P〈0．05）；ERα、ERβ、pS2在绝经前比在绝经后高，各指标在绝经前后比较都有显著性差异P〈0．01。结论 ERα、ERβ、pS2与子宫平滑肌肉瘤的发病机制有关，与子宫平滑肌肉瘤的预后有关。

Objective： To investigate the role of estrogen receptor subtypes （ER-α、ER-β）, the estrogen- induced protein （pS2） in the development and progression of uterine leiomyosarcoma, leiomyoma, and normal myometrium. Methods ： The tissues of leiomyosarcoma leiomyoma and normal myometrium from 85 uteri, which were excised for leiomyoma or leiomyosarcoma were used for the localization of the above isoforms and pS2 by immunohistochemistry. Results： The expression of ERα in leiomyosarcoma was less than myoma , It has demonstrated significant difference （ P 〈0.01 ） ; The expression of ERβ has demonstrated significant difference （ P 〈0.01）; The expression of pS2 in leiomyosarcoma was higher than myoma, It has demonstrated significant difference （ P 〈 0. 05） ; The expressions of ERα, pS2 in Ⅰ , Ⅱ , Ⅲ/Ⅳ stages have demonstrated sighificent different （ P 〈 0.05 ） ; The expression of ERα, ERβ, pS2 in pre - menopause were higher than in post - menopause, They all have sighificent different （ P＂ 〈 0. 01 ）. Conclusions： The expression of ERα, ERβ, pS2 have relations with occurrence and development of uterine leiomyosarcoma, they also have relations with prognosis.