肝动脉栓塞化疗与灌注化疗介入治疗结肠癌肝转移瘤的临床研究

Clinical Study on Effect of Trans-hepatic Arterial Embolization for Hepatic Metastasis from Colon Carcinoma

目的探讨介入化疗并栓塞方法治疗结肠癌肝转移的疗效、并发症及生存期。方法治疗组38例病人采用介入法行肝动脉栓塞化疗(TAE),对照组24例采用行肝动脉灌注化疗(TAI)。结果介入栓塞化疗组有效率为84·2%,介入灌注化疗组有效率为37·5%,两组间差异有显著性意义;介入栓塞化疗组病人6、12和24个月生存期分别为94·7%、64·5%和41·7%,而介入化疗灌注化疗组分别为58·3%、31·8%和15·0%。结论采用肝动脉栓塞化疗是结肠癌肝转移的一种有效方法,无论是疗效还是生存期,介入化疗并栓塞方法均优于灌注化疗方法。

Objective To investigate therapeutic efficacy, complication and survival period of hepatic metastasis from colon carcinoma treated by interventional chemotherapy with embolization. Methods Thirty eight patients were treated by trans - hepatic arterial embolization （TAE） chemotherapy in trial group, and twenty four patients were treated by trans - hepatic arterial infusion （TAI） chemotherapy in control group. Results The effective rate is 84. 2% （32/38） in TAE group and 37.5% （18/48） inTAIgroup （ P 〈0.01）. The six-month, one-year, two-year survival rates are 94.7%, 64. 5%, 41.7%, respectively in TAE group, and 58. 3% , 31.8% , 15.0% , respectively in TAI group. Conclusion TAE is an effect method for hepatic metastasis from colon carcinoma, and it is superior to TAI either in therapeutic efficacy or in survival period.