伊贝沙坦治疗高血压及对左心室肥厚和舒张功能影响的临床研究

Effect of Irbesartan on Hypertension and Left Ventricular Hypertrophy and Diastolic Function in Patients with Essential Hypertension

目的 观察伊贝沙坦对原发性高血压患者的降压疗效及左心室肥厚和舒张功能的影响。方法 对54例l～2级原发性高血压患者给予口服伊贝沙坦150～300mg，治疗24用，观察治疗前、后血压变化，并用超声心动图观察治疗前、后左室结构和舒张功能变化。结果 原发性高血压患者伊贝沙坦治疗后，收缩压和舒张压均较治疗前差异有显著性意义（P〈0．05），左室质量指数（LVMI），心室舒张功能较治疗前差异有显著性意义（P〈0．01），不良反应轻微。结论 伊贝沙坦有较好的降压疗效，并可逆转左心室肥厚及改善左心室舒张功能。

Objective To observe antihypertensive effect of irbesartan and its impact on left ventricular hypertrophy and diastolic function in patients with essential hypertension. Methods Fifty - four patients with 1～2 stage essential hypertension were given irbesartan 100 -300mg/d for twenty -four weeks. The change of blood pressure before and after treatment was observed, and the changes of left ventrieular structure and diastolic function before and after treatment were examined with echocardiography. Results After treatment with irbesartan, both systolic and diastolic pressure of the patients decreased （ P 〈 0. 05） , the left ventricular mass index significantly decreased （ P 〈0. 01 ） , and the left ventrieular diastolic function was obviously improved （ P 〈0. 01 ）. Conclusion Irbesartan is effective for treatment of hypertension. Irbesartan can reverse left ventricular hypertrophy, and improve left ventricular diastolic function.