肺心汤对慢性缺氧性肺动脉高压大鼠的作用研究

Effect of Feixin Tang Decoction on Chronic Oxygen-poor Pulmonary Artery Hypertension

目的:观察肺心汤对慢性缺氧性肺动脉高压大鼠的作用。方法:将大鼠置有机玻璃缺氧箱中,缺氧28天,每天缺氧8h,建立大鼠慢性缺氧性肺动脉高压模型,缺氧第15天灌胃给药,于末次给药后次日测肺动脉压(mPAP)、股动脉压(mAP)、氧分压(PaO2)、二氧化碳分压(PaCO2)和全血粘度、血浆粘度、红细胞压积。结果:肺心汤14、28g/kg能降低全血粘度、血浆粘度和红细胞压积;肺心汤28g/kg能降低mPAP,对mAP、PaO2和PaCO2无明显影响。结论:肺心汤选择性的作用于肺循环,降低血液粘稠度是其治疗肺动脉高压的机制之一。

Objective： To observe effects of Feixin Tang（FXT） on the chronic hypoxia pulmonary hypertension tats. Methods： To place the rat into organic glass box with oxygen - poor 28 days, 8 hours every day. To establish the model of chronic hypoxia pulmonary hypertension rats, the drug was taken by intragastric administration after 15 days oxygen -poor, the second day after the last administration, some targets, mPAP, mAP, PaO2, PaCO2, viscosity of whole blood and blood plasma,VPC should be examined. Result： the FXT could reduced the viscosity of whole blood and blood plasma, VPC with the concentration of 14,28g/kg; the FXT could reduce mPAP in the concentration of 28g/kg, mAP, PaO2, PaCO2, without obvious effect on mAP, PaO2, PaCO2. Conclusion： It is one of mechanisms treated the pulmonary hypertension that the FXT improve pulmonary circulation selectively and reduce the blood viscosity.