β_2-微球蛋白、唾液酸及癌胚抗原联合检测消化道癌

The Value of Determination of β_2-Microglobulin, Sialic Acidand Carcinoembryonic Antigen in the Diagnosis of Digestive Tract Cancer

对71例消化道癌（消管癌、胃癌、大肠癌）患者和24例消化道良性疾病患者进行血β2-微球蛋白（β2-MG）、唾液酸（SA）和癌胚抗原（CEA）检测。结果发现，癌症病人血β2-MG、SA和CEA含量较良性疾病明显增高（p＜0．05）；其β2-MG阳性率为62．0％，SA为29．6％，CEA为28．2％；三项标记物联合检测阳性率可提高到80．3％。实验证实，β2-MG、SA、CEA的检测对消化道癌的诊断有一定临床意义；β2-MG的阳性率明显高于SA和CEA；三者联合检测则更有助于诊断并能提高诊断的阳性率。

The serum β2-microglobulin (β2-MG), sialic acid (SA) and carcinoembryonic antigen (CEA) levelswere determined in 71 patients with digestive tract cancers (esophageal cancer, stomach cancer arid cancer of thelarge intestine) and 24 patients with benign digestive ttact diseases. The results showed that the serum β2-MG,SA and CEA levels of former were significantly higher than that of later (P<0.05). The former's positive rate ofβ2-MG was 62.0%, that of SA and CEA were 29.6% and 28.2% respectively. The positive rate can be raised to 80.3%by the combined determination of the three markers. The experiment confirmed that the determination of the se-rum β2-MG, SA and CEA level had certain value in the diagnosis of digestive tract cancers, the positive rate ofβ2-MG was highest in the three markers, and the combined determination is more helpful for the diagnosis andcan raise the positive rate of diagnosis.