P53、Ki67、Bcl-2的表达在胸腺瘤分型中的意义

Significance of P53,Ki67 and Bcl-2 expression in classification of thymoma

[目的]探讨P53、Ki67、Bcl-2的表达在不同类型胸腺瘤中的意义及其临床特征。[方法]对66例胸腺瘤进行组织学分型。A型9例;AB型11例;B1型13例;B2型10例;B3型10例;C型13例。应用免疫组织化学染色SP法,检测P53、Ki67、Bcl-2在66例不同类型胸腺瘤中表达特征。[结果]在A、AB、B1、B2、B3型及C型胸腺瘤中,P53的表达分别为22.2%、27.2%、23.1%、40.0%、60.0%、84.6%,B2、B3、C型与A、AB、B1型之间差异显著(P<0.05);Ki67高指数(Ⅲ级+Ⅳ级)表达分别为22.2%、18.1%、23.1%、40.0%、70.0%、84.6%,B2、B3、C型与A、AB、B1型之间差异显著(P<0.05);Bcl-2阳性率分别为100.0%、72.7%、23.1%、40.0%、80.0%、69.2%,B1、B2、B3型胸腺瘤呈逐渐增高趋势,存在显著差异性(P<0.05)。[结论]P53、Ki67、Bcl-2的表达在不同类型胸腺瘤中差异显著,有助于判断胸腺瘤良恶性,对临床预后评估有重要参考价值。

[Objective] To study clinic signification detecting expressions of P53, Ki67 and Bcl- 2 in thymoma different types. [ Methods] The 66 cases of thymomas were detected by SP immunohistochemical method including type A 9 cases, type AB 11 cases, type B1 13 cases, type B2 10 cases, type B3 10 cases and type C 13 cases. [ Results] In the thymoma type A, AB, B1, B2, B3, and type C, the expression rates of P53 were 22.2%, 27.2% ,23.1% ,40.0% ,60.0% and 84.6% respectively. The rates of B2, B3 and C types were significantly higher than those of A, AB and B1 types in 66 thymomas. （P 〈 0.05 ）The high index （grade Ⅲ and grade Ⅳ） expression rates were 22.2%, 18.1%, 23.1%, 40.0%, 70.0% and 84.6%. The rates of B2, B3 and C types were significantly higher than those of A,AB and B1 types in 66 thymoma. （ P 〈 0.05 ）The expression rates of Bcl-2 were 100.0%,72.7%, 23. 1%, 40.0%, 80.0% and 69.2% respectively, there were obvious increasing tendency in B2, B3 and C type, and there were obvious difference. （ P 〈 0.05 ） [ Conclusion] The detection of P53 , Ki67 and Bcl- 2 expression may be helpful to judge malignancy thymoma.