长托宁用于心脏病人非心脏手术前用药的临床研究

Clinical research of penehyclidine hydrochloride as premedicent of general anesthesia in cardiac patient undergoing noncardiac surgery

[目的]探讨长托宁作为心脏病人非心脏手术前用药的临床效果。[方法]ASAⅡ-Ⅲ级的病人50例,随机分为长托宁组和东莨菪碱组,免用术前药,入室后肌注长托宁0.01 mg/kg和东莨菪碱0.006 mg/kg,40 min后开始麻醉和手术。记录给药前、给药后10、20、30、40 min时的心率(HR)、血压(Bp)变化情况及观察病人镇静、口干程度。[结果]Ⅰ组SBP在给药后30、40 min时低于给药前;DBP在20、30、40 min时较给药前低;HR在20、30 min时较给药前低,(P<0.05)。Ⅱ组SBP、DBP在给药后30 min时均较用药前高,且明显高于Ⅰ组,(P<0.05)。HR在20、30、40min时高于给药前,且较Ⅰ组明显增快,(P<0.05)。组间比较口干与镇静程度均没有显著差异。[结论]长托宁作为心脏病人非心脏手术前用药较东莨菪碱效果好。

[ Objective] To research the effects of perehyclidine hydrochloride as premedicent in cardiac patient during noncardiac surgery. [ Methods] Fifty patients with ASA Ⅱ - Ⅲ were randomly divided into two group ： perehyclidine hydrochloride group, received perehyclidine hydrochloride 0.01 mg/kg imand group scopolamine , received scopolamine 0. 006 mg/kg im. HR, Bp Thirstiness and sedation were recorded on 4 time- points： before injection, 10 minutes, 20 minutes, 30 minutes after injection. [ Resuhs] Perehyclidine hydrochloride decreased blood pressure and heart rates significantly especially SBP in 30,40minutes after injection, DBP in 20, 30,40 minutes after injection and HR in 20,30minutes after injection （P 〈 0.05）. scopolamine increased blood pressure and heart rates significantly compared with perehyclidine hydrochloride especially Bp in 30minutes after injection and HR in 20, 30, 40minutes after injection（ P 〈 0.05）. There were no significant differences in thirstiness and sedation between two groups. [ Conclusions] Perehyclidine hydrochloride is a better choice of premedicent for cardiac patients undergoing noncardiac surgery.