大剂量氨甲喋呤治疗儿童急性淋巴细胞白血病的药代动力学

Pharmacokinetics of Large Dose Methotrexate in the Treatment of Child Patients With Acute Lymphocytic Leukemia

本文运用放射免疫分析（ｒａｄｉｏｉｍｍｕｎｏａｓｓａｙ，ＲＩＡ）的方法测定１０例大剂量氨甲喋呤（Ｍｅｔｈｏｔｒｅｘａｔｅ，ＭＴＸ３９／ｍ２）１２小时静滴治疗儿童急性淋巴细胞白血病患儿的血药浓度，结果用《实用药代动力学计算程序３ｐ８７》判断符合二室模型，计算出药动学参数ｔ１／２α（ｈ）＝０．３９５４±０．０４６８，和ｔ１／２（ｈ）＝４．５６４７±０．０９１４，Ｋ１２（ｈ－１）＝０．５±０．０９３１。Ｋ２１（ｈ－１）＝０．２２４１±０．００９５，Ｋ１０（ｈ－１）＝１．１９９３±０．１２１３。

Using radioimmunoassay,the serum concentrations of large dose methotrexate (3g/m2iv 12h)were determined in 10 child patients with acute lymphocytic leukemia. computed by practical pharmacokinetic computer program 3p87,the results could be described by two compartment model. The pharmacokinetic parameters were as follow:t1/2α(h)=0.3 954±0.0468,t1/2β(h)=4.5 647±0.0 914,K12(h-1)=0.5±0.0 931,K21(h-1)=0.2 241±0.0 095,K10(h-1)=1.1 993±0. 1 213.