伊索显280与欧乃派克300脑血管造影随机双盲临床对比试验

Randomized Double-blind Clinical Trial of the X-ray Contrast Media Isovist 280 VS Omnipaque 300 for Cerebral Angiography

本文报告５８例伊索显２８０与欧乃派克３００脑血管造影对比随机双盲临床试验，其中３０例应用伊索显２８０，２８例应用欧乃派克３００实验。实验证明大多数调查者认为两种造影剂的质量好（伊索显占９２．６％，欧乃派克占９４．３％）。在检查期间，两组的副反应显示率相似（ｐ＞０．０５，无显著差异）。检查后，在大组中伊索显２８０总的副反应率低于欧乃派克３００（ｐ＜０．０５，有显著差异）检查后，在大组中伊索显２８０头痛的发生率明显低于欧乃派克３００（ｐ＜０．０５，有极显著差异）。伊索显２８０副反应的病例比欧乃派克副反应的病例少，程度轻，因此伊索显２８０对脑血管造影是一种有效、耐受性好和安全的造影剂。

This paper reports a randomized double-blind clinical trial of two kinds of X-ray contrast media,Isovist 280 (30 cases) and Omnipaque 300 (28 cases), for cerebral angiography in 58 patients.Most investigators considered the contrast quality of both media satisfactory (92.6% for Isovist and 94.3% for Omnipaque). During contrast examination, there was no significant difference (p>0.05) in side effects induced by two kinds of contrast media. After examination, the total side effect rate of Isovist was lower than that of Omnipaque (p<0.05), moreover, Isovist induced less headache.We consider that Isovist 280 is an effective, well-tolerated and safe X-ray contrast medium for cerebal angiography.