纤维蛋白原和红细胞比积在2型糖尿病微血管病变中的临床意义分析

The clinical significance of plasma fibrinogen and Hematocrit in Type 2 Diabetic Microangiopathy

目的探讨血浆纤维蛋白原和红细胞比积在糖尿病微血管病变的发生和发展过程中的作用。方法按统一要求测定124例糖尿病患者及30例正常人的血浆纤维蛋白原和红细胞比积。结果糖尿病患者血浆纤维蛋白原和红细胞比积均明显升高(P<0.01),在伴有微血管病变中变化更明显(P<0.01)。结论两者共同参与了糖尿病微血管病变的发生和发展。

Objective To explore the role of plasma fibrinogen and hematociit in the pathogenesis of type 2 diabetic mieroangiopathy. Methods The levers of plasma fibfinogen and hematoerit were measured in 30 norreal subjects 60 diabetics without mieroangiopathy and 64 diabetics with mieroangiopathy. Results The plasma and hematoerit levels were markedly higher in diabetics without mieroangiopathy and with microangiopathy than those in normal subjects （P〈0.01）, the changes of plasma fibrinogen and hematoefit in diabetics with mieroangiopathy were significantly greater than without mieroangiopathy （P〈0.01）. Conclusions The increase of plasma fibrinogen and hematoefit were played a important role in the pathogenesis of diabetic mieroangiopathy.