慢性乙型肝炎病理舌苔形成与唾液、血清h-EGF含量变化的关系

Relationship between Pathological Tongue Fur and Content of Epidermal Growth Factor in Saliva and Serum of Patient with Chronic Hepatitis B

目的研究慢性乙型肝炎患者舌苔变化与唾液、血清表皮生长因子(h-EGF)含量变化及舌苔上皮细胞表皮生长因子受体(h-EGFR)的关系,探讨唾液血清h-EGF在乙肝病理舌苔形成中的作用。方法选取128例慢性乙型肝炎患者为研究对象,以15例其它消化系统疾病、15例其它系统疾病及15例健康人做对照组,放免法检测受试者唾液、血清h-EGF含量,免疫组化法检测舌苔上皮细胞h-EGFR表达,观察并记录病理舌象进行分析。结果与正常对照组相比,病理厚苔组唾液、血清h-EGF含量明显升高(P<0.01)。乙肝组白厚(腻)苔、黄腻苔舌h-EG FR表达增强,唾液、血清h-EG F含量明显升高,与其它对照组相比差异有统计学意义(P<0.01)。结论慢性乙肝病理舌苔的形成与唾液h-EGF含量的改变有关。

Objective To study the relationship between the change of abnormal tongue fur, epidermal growth factor receptor （h-EGFR） of epithelial cells of tongue and the content change of epidermal growth factor （h-EGF） in saliva and serum of the patient with chronic hepatitis B, and explore the action of h-EGF on formation of abnormal tongue fur. Methods The subject group was 128 patients with chronic hepatitis B and the control group was 15 patients with other diseases in digestive system, 15 patients with other system diseases and 15 healthy people. The h-EGF in saliva and serum from the subjects was detected with radioimmunoassay and h-EGFR of epithelial cells of tongue with Immunity Histochemistry, and the abnormal tongue condition was observed and recorded. Results Camparied with healthy group, h-EGF in saliva and serum from the patients was higher obviously （P〈0.01）. In the group of hepatitis B with white thick（greasy） and yellow greasy tongue fur, expression of h-EGFR was increased, and the volume of h-EGF was higher, which was different significantly（P〈0.01） compared with other groups. Conclusion The formation of abnormal tongue fur in the patient with chronic hepatitis B is related to the level of saliva h-EGF.