应用BiPAP治疗COPD的临床疗效观察

Clinical Study of the Noninvasive Mechanical Ventilation for Treatment of Chronic Obstructive Pulmonary Disease

目的:观察无创正压机械通气对慢性阻塞性肺疾病(COPD)的临床治疗效果。方法:在80例COPD患者中随机选择了40例进行规律性无创双水平气道正压机械通气辅助治疗,每日上机两次,每次2h,2周为一疗程。比较上机前、上机2h、24h、1周、2周后动脉血气中pH值,PaO2值,PaCO2值及临床症状变化情况。结果:治疗组治疗2h、24h、1周、2周后动脉血气中pH值和PaO2值逐步上升,PaCO2值逐步下降,临床症状明显改善,有效率为87.5%(35/40)。对照组动脉血气中pH值,PaO2,PaCO2值及临床表现虽有不同程度的改善,但与治疗组同期比较,差异均有显著性(P<0.05)。结论:无创双水平气道正压机械通气辅助治疗COPD具有显著的临床治疗效果。

Objective： To evaluate the clinical efficacy of noninvasive mechanical ventilation for the treatment of patients with chronic obstructive pulmonary disease （ COPD ）. Method： Eighty COPD patients were divided equally at random into two groups （ 1 ） mechanical ventilation and （ 2 ） no mechanical ventilation （ as control ）. The first groups was treated with double channel noninvasive mechanical ventilator twice a day and 2 hours per time, each course lasted for 2 weeks. Arterial blood pHi PaO2 and PaCO2 were measured and changes of clinical symptoms were recorded in both groups before and 2 hours, 24 hours, 1 week and 2 weeks after treatment, respectively. Result： In first group, artefical Ph and PaO2 elevated gradually, accompany with gradual decline of PaCO2 and prominently clinical symptoms. Its effective rate of treatment was 87. 5 % （35/40）. As for the control group, three parameters of arterial blood and clinical symptoms were＇ also improved to a certain degree, but significant difference existed as compared with the first group （ P 〈 0.05 ）. Conclusion ： Noninvasive mechanical ventilation as an auxiliary treatment is definitely valuable for COPD patients.