拉米夫定治疗30例HBV引起的失代偿性肝病

Lamivudine treatment for 30 cases decompensated liver diseases caused HBV.

观察拉米夫定治疗HBV引起的失代偿性肝病的近期疗效。选择18例慢性重型乙型肝炎、12例失代偿性肝硬化患者在综合治疗基础上,口服拉米夫定(100mg/d),观察6个月患者的临床表现、肝功能、病毒学指标、Ch ild-Pugh记分及HBV DNA变化情况。提示拉米夫定能迅速有效地改善多数HBV引起的失代偿性肝病患者的临床症状及肝功能,使患者HBV DNA阴转,可提高HBV引起的失代偿性肝病患者生存率。

To observe the short -term effect of lamivudine therapy on decompensated liver diseases caused by HBV. 18 cases with chronic severe hepatitis B and 12 cases with decompensated cirrhosis were given lamivudine 100mg daily and combined therapy. After 6 months efficacy was assessed by clinical, biochemical and virologic parameters. After 6 months treatment of lamivudine, Child -Pugh scores significant decreasing, HBV - DNA rapidly changes from positive to negative, clinical improvement in most patients. Lavmiuvdine is effective for treatment decompensated liver diseases caused by HBV.