病毒性肝炎患者血清视黄醇结合蛋白检测的临床意义

Clinical significance of serum Retinal-binding protein detection in viral hepatitis patients

为了解血清视黄醇结合蛋白(RBP)在各型病毒性肝炎中的变化,探讨测定血清RBP对病毒性肝炎患者的诊断价值。分别检测161例不同类型的肝炎患者及正常对照组的血清RBP、前白蛋白(PA)、白蛋白(ALB)水平,并进行统计分析。发现除慢性肝炎轻度组外,各组肝病患者血清RBP、PA均显著低于对照组(P<0.05);且异常率均高于同组PA、ALB的异常率(P<0.05)。重型肝炎组死亡者RPB、PA均显著低于存活者,死亡者与存活者之间的RBP有极显著性差异(P<0.01)。提示血清RBP可作为判断急性肝损害的灵敏指标。能更准确地反映肝脏贮备功能,对估计重型肝炎、肝炎后肝硬化的预后有重要的参考价值。

To study changes of retinal - binding protein （RBP） in different types of viral hepatitis and to explore RBP＇s diagnostic value in viral hepatitis patients. Serum RBP, PA and ALB were detected respectively in acute hepatitis patients, chronic hepatitis patients mild, middle and Severe degree）, hepatitis gravis patients, cirrhosis patients （compensatory phase and decompensatory phase） and normal control. Statistical analysis was done. The level of RBP and PA of all hepatopath except chronic mild hepatitis decreased apparently compared with control group. （P 〈 0. 05） The abnormal rate of RBP was higher than that of PA and ALB in all hepatopath. （P 〈 0. 05 ） The level of RBP and PA of dead patients was lower significantly than that of survival and the difference of RBP was very significant between two groups （P 〈 0. 01 ）. Serum RBP was a sensitive index in judging acute and chronic liver injury. Serum RBP could reflect liver＇s reserved function exactly and had important reference value in estimating prognosis of hepatitis gravis and hepatitis cirrhosis.