丙型肝炎病毒感染者血清中自身抗体检测结果分析

Detection and analysis of serum autoantibodies in patients with hepatitis C

为观察丙型肝炎病毒(HCV)感染者血清中自身抗体的变化情况,探讨自身免疫反应在丙型肝炎中的作用,我们以间接免疫荧光法对92例HCV感染者血清标本测定抗核抗体(ANA)、可提取性核抗原抗体(ENA)、抗线粒体抗体(AMA),抗平滑肌抗体(SMA),并根据荧光反应模式判定结果为:HCV感染者92例中有36例出现自身抗体,检出率为39.1%,高于慢性乙型肝炎自身抗体检出率12.8%(P<0.05),明显高于正常对照组的2.4%(P<0.01)。其中HCV感染者ENA阳性率为16.8%,由此可知,HCV感染后可出现自身免疫反应,自身免疫可能是HCV感染后组织损伤的重要因素。

To analyze the changement of serum autoantibodies in patients infaeted with hepatitis C virus （HCV）, and to investigate the role of autoimmune reaction in patients with hepatitis C. ANA,ENA,AMA,SMA were detected using indirect fluoroimmunoassay technology in 92 patients with hepatiti C. The positive rate of autoantibodies was 39.1% in patients with hepatitis C. It was higher than that in control group. The positive rate of anti - ENA antibody was 16.8% in patients with hepatitis C. So autoimmune reaction may be present in patients infected with HCV. We suggest that autoimmune reaction is an immporant factor in hepatocyte injuries in patients with hepatitis C.