1Radziwill G,Tucker W,Schaller H.Mutational analysis of the bepatitis B virus P gene product:domain structure and Rnase H activity[J].J Virol,1990,64:613 -20.
2Poch O,Sauvaget I,Delarue M,et al.Identification of four conserved motifs among the RNA-dependent polymerase encoding elements[J].EMBO J,1989,18:3867 -74.
3Seeger C,Manson WS.Hepatitis B virus biology[J].Microbiol Mol Biol Rev,2000,64:51 -68.
4Xiong X,Yang H,Christopher E,et al.In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance[J].Hepatology,2000,31:219 -24.
5McGarvey MJ,Goldin RD,Karayiannis P,et al.The expression of hepatitis B virus polymerase in hepatocytes during chronic HBV infection[J].J Viral Hepat,1996,3:6773.
6Foster GR,Golden RD,Hay A,et al.Expression of the terminal protein of hepatitis B virus is associated with failure to respond to interferon therapy[J].Hepatology,1993,17:75762.
7Tavis JE,Massey B,Gong Y.The duck hepatitis B virus polymerase is activated by its RNA packaging signal,epsilon[J].J Virol,1998,72:5789-96.
8Hussain M,Lok AS.Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B[J].J Viral Hepat,1999,6:183-94.
9Chen WN,Oon CJ.Human hepatitis B virus mutants:significance of molecular changes[J].FEBS,1999,453:237 -242.
10Melegari M,Scaglioni PP,Wands JR.Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective[J].Hepatology,1998,27:628-33.
二级参考文献15
1Seeger C et al. Microbiol Mol Biol Rev,2000;64:51-68
2Yao E et al. J Virol,2000;74:8648-8657
3Nassal M et al.J.Viral Hepat, 1996;3:217-226
4Kramvis A et al.J Viral Hepat,1998;5:357-367
5Tavis JE et al. J Virol, 1998;72:5789-5796
6Gong Y et al. J Gen Virol,2000;8:2059-2065
7Cebulla CM et al.Intervirology,1999;42:325- 330
8Maini MKC et al. Gastroenterology, 1999; 117:1386-1396
9zu Putlitz JRE et al. J Virol, 1999;73:4188;- 4196
10Rosmorduc OH et al. J G en Virol, 1999; 80:1253-1262